General Information

  • ID:  hor006309
  • Uniprot ID:  Q8BFS3
  • Protein name:  Relaxin-3 A chain
  • Gene name:  Rln3
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Insulin family
  • Source:  Animal
  • Expression:  Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DVLAGLSSSCCEWGCSKSQISSLC
  • Length:  24(117-140)
  • Propeptide:  MATRGLLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVGSSEWLALTKSPQVFYGGRSSWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC
  • Signal peptide:  MATRGLLLASWALLGALVLQAEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Rxfp1, Rxfp3
  • Target Unid:  Q6R6I6, Q5Y986
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45945
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006309_AF2.pdbhor006309_ESM.pdb

Physical Information

Mass: 287423 Formula: C100H163N27O37S4
Absent amino acids: FHMNPRTY Common amino acids: S
pI: 4.18 Basic residues: 1
Polar residues: 13 Hydrophobic residues: 7
Hydrophobicity: 42.5 Boman Index: -1556
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 81.25
Instability Index: 4468.33 Extinction Coefficient cystines: 5750
Absorbance 280nm: 250

Literature

  • PubMed ID:  12354304
  • Title:  Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain.
  • PubMed ID:  12686464
  • Title:  Production of recombinant human relaxin 3 in AtT20 cells.